Warnings


What may interact with Annovera?

Do not take this medication with the following:
-Dasabuvir, ombitasvir, paritaprevir, ritonavir
-Ombitasvir, paritaprevir, ritonavir
-Vaginal lubricants or other vaginal products that are oil-based or silicone-based
This medication may also interact with the following:
-Acetaminophen
-Antibiotics or medications for infections, such as rifampin, rifabutin, rifapentine, and griseofulvin
-Aprepitant or fosaprepitant
-Armodafinil
-Ascorbic acid (vitamin C)
-Barbiturate medications, such as phenobarbital or primidone
-Bosentan
-Certain antiviral medications for hepatitis, HIV or AIDS
-Certain medications for cancer treatment
-Certain medications for seizures, such as carbamazepine, clobazam, felbamate, lamotrigine, oxcarbazepine, phenytoin, rufinamide, topiramate
-Certain medications for treating high cholesterol
-Cyclosporine
-Dantrolene
-Elagolix
-Flibanserin
-Grapefruit juice
-Lesinurad
-Medications for diabetes
-Medications to treat fungal infections, such as griseofulvin, miconazole, fluconazole, ketoconazole, itraconazole, posaconazole, voriconazole
-Mifepristone
-Mitotane
-Modafinil
-Morphine
-Mycophenolate
-St. John''s Wort
-Tamoxifen
-Temazepam
-Theophylline or aminophylline
-Thyroid hormones
-Tizanidine
-Tranexamic acid
-Ulipristal
-Warfarin

What should I tell my health care provider before I take Annovera?

They need to know if you have any of these conditions:
-Abnormal vaginal bleeding
-Blood vessel disease or blood clots
-Breast, cervical, endometrial, ovarian, liver, or uterine cancer
-Diabetes
-Gallbladder disease
-Having surgery
-Heart disease or recent heart attack
-High blood pressure
-High cholesterol or triglycerides
-History of irregular heartbeat or heart valve problems
-Kidney disease
-Liver disease
-Migraine headaches
-Protein C/S deficiency
-Recently had a baby, miscarriage, or abortion
-Stroke
-Systemic lupus erythematosus (SLE)
-Tobacco use
-An unusual or allergic reaction to estrogens, progestins, other medications, foods, dyes, or preservatives
-Pregnant or trying to get pregnant
-Breast-feeding

What should I watch for while using Annovera?

Visit your care team for regular checks on your progress. You will need a regular breast and pelvic exam and Pap smear while on this medication.
Check with your care team to see if you need an additional method of contraception during the first cycle that you use this ring. External condoms made with natural rubber latex, polyisoprene, and polyurethane and spermicides may be used. Do not use a diaphragm, cervical cap, or internal condom, as it is unknown if this ring can interfere with these contraceptive methods and their proper placement.
If you have any reason to think you are pregnant, stop using this medication right away and contact your care team.
If you are taking this medication for hormone-related problems, it may take several cycles of use to see improvement in your condition.
Talk to your care team if you use tobacco products. Changes to your treatment plan may be needed. Tobacco increases the risk of getting a blood clot or having a stroke while you are taking this medication. The risk is higher if you are over the age of 35 years.
You may get dark patches on your face (chloasma) while taking this medication. If you noticed dark patches on your face during a pregnancy, your risk of getting it is higher. Keep out of the sun. If you cannot avoid the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning booths.
This medication can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your care team if you feel you are retaining fluid.
If you are going to have elective surgery, you may need to stop using this medication before the surgery. Consult your care team for advice.
This medication does not protect you against HIV infection (AIDS) or any other sexually transmitted infections.

Where should I keep my medicine?

Keep out of the reach of children and pets.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light. Between each cycle of use, wash and dry the ring as directed and store in the case. Get rid of any medication after the expiration date. The ring should be placed in the case after 13 cycles (1 year) of use and discarded via a medication take-back option, if available. If not, then discard in the trash out of reach of children and pets. Do NOT flush down the toilet.