Do not take this medication with any of the following:
-Cyclosporine
-Estrogen or progestin hormones
-Glyburide
This medication may also interact with the following:
-Amiodarone
-Amprenavir
-Certain medications for cholesterol, such as atorvastatin, lovastatin, and simvastatin
-Certain medications for fungal infections, such as fluconazole, ketoconazole, and itraconazole
-Diltiazem
-Erythromycin
-Rifampin
-Ritonavir

They need to know if you have any of these conditions:
-Liver disease
-An unusual or allergic reaction to bosentan, other medications, foods, dyes, or preservatives
-Pregnant or trying to get pregnant
-Breast-feeding

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.
You may need blood work done while you are taking this medication.
This medication may cause serious skin reactions. They can happen weeks to months after starting the medication. Contact your care team right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. You may also notice a red rash with swelling of the face, lips, or lymph nodes in your neck or under your arms.
Talk to your care team if you may be pregnant. Serious birth defects can occur if you take this medication during pregnancy and for 1 month after your last dose. You will need a negative pregnancy test before, during, and after taking this medication. Estrogen and progestin hormones may not work as well while you are taking this medication. Contraception is recommended while taking this medication and for 1 month after your last dose. Your care team can help find the option that works for you.
Do not breastfeed while taking this medication.
This medication may cause infertility. Talk to your care team if you are concerned about your fertility.

Keep out of the reach of children and pets.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Get rid of any unused medication after the expiration date.
To get rid of medications that are no longer needed or have expired:
-Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.