Do not take this medication with any of the following:
-Desvenlafaxine
-Levomilnacipran
-Linezolid
-MAOIs, such as Carbex, Eldepryl, Emsam, Marplan, Nardil, and Parnate
-Methylene blue (injected into a vein)
-Milnacipran
-Safinamide
-Thioridazine
-Venlafaxine
-Viloxazine
This medication may also interact with the following:
-Alcohol
-Amphetamines
-Aspirin and aspirin-like medications
-Certain antibiotics, such as ciprofloxacin and enoxacin
-Certain medications for blood pressure, heart disease, irregular heart beat
-Certain medications for mental health conditions
-Certain medications for migraine headache, such as almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan
-Certain medications that treat or prevent blood clots, such as warfarin, enoxaparin, and dalteparin
-Cimetidine
-Fentanyl
-Lithium
-NSAIDS, medications for pain and inflammation, such as ibuprofen or naproxen
-Phentermine
-Procarbazine
-Rasagiline
-Sibutramine
-St. John''s Wort
-Theophylline
-Tramadol
-Tryptophan

They need to know if you have any of these conditions:
-Bipolar disorder
-Glaucoma
-High blood pressure
-Kidney disease
-Liver disease
-Seizures
-Suicidal thoughts, plans, or attempt by you or a family member
-Take medications that treat or prevent blood clots
-Taken an MAOI, such as Carbex, Eldepryl, Marplan, Nardil, or Parnate in the last 14 days
-Trouble passing urine
-An unusual reaction to duloxetine, other medications, foods, dyes, or preservatives
-Pregnant or trying to get pregnant
-Breastfeeding

Tell your care team if your symptoms do not get better or if they get worse. Visit your care team for regular checks on your progress. Because it may take several weeks to see the full effects of this medication, it is important to continue your treatment as prescribed by your care team.
This medication may cause serious skin reactions. They can happen weeks to months after starting the medication. Contact your care team right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. You may also notice a red rash with swelling of the face, lips, or lymph nodes in your neck or under your arms.
Watch for new or worsening thoughts of suicide or depression. This includes sudden changes in mood, behaviors, or thoughts. These changes can happen at any time but are more common in the beginning of treatment or after a change in dose. Call your care team right away if you experience these thoughts or worsening depression.
This medication may cause mood and behavior changes, such as anxiety, nervousness, irritability, hostility, restlessness, excitability, hyperactivity, or trouble sleeping. These changes can happen at any time but are more common in the beginning of treatment or after a change in dose. Call your care team right away if you notice any of these symptoms.
This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.
This medication may increase blood sugar. The risk may be higher in patients who already have diabetes. Ask your care team what you can do to lower your risk of diabetes while taking this medication.
This medication can cause an increase in blood pressure. This medication can also cause a sudden drop in your blood pressure, which may make you feel faint and increase the chance of a fall. These effects are most common when you first start the medication or when the dose is increased, or during use of other medications that can cause a sudden drop in blood pressure. Check with your care team for instructions on monitoring your blood pressure while taking this medication.
Your mouth may get dry. Chewing sugarless gum or sucking hard candy and drinking plenty of water may help. Contact your care team if the problem does not go away or is severe.

Keep out of the reach of children and pets.
Store at room temperature between 15 and 30 degrees C (59 to 86 degrees F). Get rid of any unused medication after the expiration date.
To get rid of medications that are no longer needed or have expired:
-Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, take the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.