Do not take this medication with any of the following:
-Certain medications for fungal infections, such as itraconazole, ketoconazole, posaconazole, voriconazole
-Cisapride
-Droneradone
-Levoketoconazole
-Olanzapine; samidorphan
-Pimozide
-Quinidine
-Rasagiline
-Safinamide
-Selegiline
-Thioridazine
-Ziprasidone
This medication may also interact with the following:
-Alcohol
-Antihistamines for allergy, cough, and cold
-Atropine
-Benzodiazepines, such as alprazolam, diazepam, lorazepam
-Certain medications for bladder problems, such as oxybutynin or tolterodine
-Certain medications for depression, anxiety, or other mental health conditions
-Certain medications for migraines, such as sumatriptan
-Certain medications for Parkinson disease, such as benztropine or trihexyphenidyl
-Certain medications for seizures, such as phenobarbital or primidone
-Certain medications for stomach problems, such as dicyclomine or hyoscyamine
-Certain medications for travel sickness, such as scopolamine
-Diuretics
-Ipratropium
-Linezolid
-Medications that cause drowsiness before a procedure, such as propofol
-Medications that help you fall asleep
-Medications that relax muscles
-Methylene blue
-Other medications that cause heart rhythm changes
-Other opioids for pain or cough
-Phenothiazines, such as chlorpromazine or prochlorperazine
-St. John''s wort
-Stimulant medications for ADHD, weight loss, or staying awake
-Tryptophan
Other medications may affect the way this medication works. Talk with your care team about all of the medications you take. They may suggest changes to your treatment plan to lower the risk of side effects and to make sure your medications work as intended.

They need to know if you have any of these conditions:
-Brain tumor
-Frequently drink alcohol
-Head injury
-Heart disease
-Kidney disease
-Liver disease
-Low adrenal gland function
-Low blood pressure
-Lung or breathing disease, such as asthma
-Mental health conditions
-Seizures
-Stomach or intestine problems
-Substance use disorder
-Taken an MAOI, such as Marplan, Nardil, or Parnate in the last 14 days
-Thyroid disease
-An unusual or allergic reaction to methadone, other medications, foods, dyes, or preservatives
-Pregnant or trying to get pregnant
-Breastfeeding

If you are using this medication for pain, tell your care team if your pain does not go away, if it gets worse, or if you have new or a different type of pain. You may develop tolerance to this medication. Tolerance means that you will need a higher dose of the medication for pain relief. Tolerance is normal and is expected if you take this medication for a long time.
If you are using this medication for opioid use disorder, visit your care team regularly. For this medication to be most effective, you should attend any counseling or support groups that your care team recommends. Do not try to overcome the effects of the medication by taking large amounts of opioids. This can cause severe problems including death. Also, you may be more sensitive to lower doses of opioids after you stop taking this medication.
Wear a medical ID bracelet or chain. Carry a card that describes your condition. List the medications and doses you take on the card.
Taking this medication with other substances that cause drowsiness, such as alcohol, benzodiazepines, or other opioids can cause serious side effects. Give your care team a list of all medications you use. They will tell you how much medication to take. Do not take more medication than directed. Call emergency services if you have problems breathing or staying awake.
Long term use of this medication may cause your brain and body to depend on it. This can happen even when used as directed by your care team. You and your care team will work together to determine how long you will need to take this medication. If your care team wants you to stop this medication, the dose will be slowly lowered over time to reduce the risk of side effects.
Naloxone is an emergency medication used for an opioid overdose. An overdose can happen if you take too much of an opioid. It can also happen if an opioid is taken with some other medications or substances such as alcohol. Know the symptoms of an overdose, such as trouble breathing, unusually tired or sleepy, or not being able to respond or wake up. Make sure to tell caregivers and close contacts where your naloxone is stored. Make sure they know how to use it. After naloxone is given, the person giving it must call emergency services. Naloxone is a temporary treatment. Repeat doses may be needed.
This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.
This medication will cause constipation. If you do not have a bowel movement for 3 days, call your care team.
Your mouth may get dry. Chewing sugarless gum or sucking hard candy and drinking plenty of water may help. Contact your care team if the problem does not go away or is severe.
Talk to your care team if you may be pregnant. Prolonged use of this medication during pregnancy can cause temporary withdrawal in a newborn.
Talk to your care team before breastfeeding. Changes to your treatment plan may be needed. If you breastfeed while taking this medication, seek medical care right away if you notice the child has slow or noisy breathing, is unusually sleepy or not able to wake up, or is limp.
Long-term use of this medication may cause infertility. Talk to your care team if you are concerned about your fertility.

Keep out of the reach of children. This medication can be abused. Keep it in a safe place to protect it from theft. Do not share it with anyone. It is only for you. Selling or giving away this medication is dangerous and is against the law.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Keep container tightly closed. Get rid of any unused medication after the expiration date.
This medication may cause harm and death if it is taken by other adults, children, or pets. It is important to get rid of the medication as soon as you no longer need it or it is expired. You can do this in two ways:
-Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medication, flush it down the toilet.