Warnings


What may interact with Warfarin?

Do not take this medication with any of the following:
-Defibrotide
This medication may also interact with the following:
-Acyclovir
-Allopurinol
-Aprepitant
-Armodafinil
-Aspirin
-Bicalutamide
-Bosentan
-Caffeine
-Capecitabine
-Certain antibiotics, such as erythromycin, clarithromycin, ciprofloxacin, cotrimoxazole, metronidazole, norfloxacin, or tigecycline
-Certain antivirals for HIV or hepatitis
-Certain medications for blood clots, such as argatroban, aspirin, bivalirudin, enoxaparin, fondaparinux, heparin, or lepirudin
-Certain medications for blood pressure, heart disease, irregular heartbeat
-Certain medications for cholesterol, such as atorvastatin, lovastatin, and simvastatin
-Certain medications for fungal infections, such as fluconazole, ketoconazole, itraconazole, posaconazole, or voriconazole
-Certain medications for mental health conditions
-Certain medications for seizures, such as carbamazepine, phenobarbital, phenytoin, rufinamide
-Cilostazol
-Clopidogrel
-Conivaptan
-Cyclosporine
-Dipyridamole
-Disulfiram
-Estrogen or progestin hormones
-Herbal or dietary products, such as garlic, ginkgo, ginseng, green tea, kava kava, red yeast rice, St. John''s Wort
-Isoniazid
-Methoxsalen
-Modafinil
-Nilotinib
-NSAIDs, medications for pain and inflammation, such as ibuprofen or naproxen
-Oxandrolone
-Phenylpropanolamine
-Prasugrel
-Rifampin
-Steroid medications, such as prednisone or cortisone
-Stomach acid blockers, such as cimetidine, famotidine, ranitidine, or omeprazole
-Sulfinpyrazone
-Thiabendazole
-Ticlopidine
-Vitamin K
-Zafirlukast
-Zileuton

What should I tell my health care provider before I take Warfarin?

They need to know if you have any of these conditions:
-Alcohol use disorder
-Anemia
-Bleeding disorders
-Cancer
-Diabetes
-Heart disease
-High blood pressure
-History of bleeding in the gastrointestinal tract
-History of stroke or other brain injury or disease
-Kidney or liver disease
-Protein C deficiency
-Protein S deficiency
-Psychosis or dementia
-Recent injury, recent or planned surgery or procedure
-An unusual or allergic reaction to warfarin, other medications, foods, dyes, or preservatives
-Pregnant or trying to get pregnant
-Breast-feeding

What should I watch for while using Warfarin?

Visit your care team for regular checks on your progress. You will need to have a blood test called a PT/INR regularly. The PT/INR blood test is done to make sure you are getting the right dose of this medication. It is important to not miss your appointment for the blood tests. When you first start taking this medication, these tests are done often. Once the correct dose is determined and you take your medication properly, these tests can be done less often.
Wear a medical ID bracelet or chain, and carry a card that describes your disease and details of your medication and dosage times.
Do not start taking or stop taking any medications or over-the-counter medications except on the advice of your care team.
You should discuss your diet with your care team. Do not make major changes in your diet. Vitamin K can affect how well this medication works. Many foods contain vitamin K. It is important to eat a consistent amount of foods with vitamin K. Other foods with vitamin K that you should eat in consistent amounts are asparagus, basil, black-eyed peas, broccoli, brussel sprouts, cabbage, green onions, green tea, parsley, green leafy vegetables like beet greens, collard greens, kale, spinach, turnip greens, or certain lettuces like green leaf or romaine.
Talk to your care team if you wish to become pregnant or think you might be pregnant. This medication can cause bleeding and serious birth defects.
Avoid sports and activities that might cause injury while you are using this medication. Severe falls or injuries can cause unseen bleeding. Be careful when using sharp tools or knives. Consider using an electric razor. Take special care brushing or flossing your teeth. Report any injuries, bruising, or red spots on the skin to your care team.
If you have an illness that causes vomiting, diarrhea, or fever for more than a few days, contact your care team. Also, check with your care team if you are unable to eat for several days. These problems can change the effect of this medication.
Even after you stop taking this medication, it takes several days before your body recovers its normal ability to clot blood. Ask your care team how long you need to be careful. If you are going to have surgery or dental work, tell your care team that you have been taking this medication.

Where should I keep my medicine?

Keep out of the reach of children and pets.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light. Throw away any unused medication after the expiration date. Do not flush down the toilet.